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A potential link between erectile dysfunction drugs and melanoma may exist, but inconsistencies in the data make a cause-and-effect relationship questionable, an analysis of a large melanoma database suggests. The analysis involved a total of 24,390 men. They identified a total of 4,065 men with newly diagnosed melanoma during the study period, including 435 who had a history of PDE5 inhibitor use. Several studies have provided evidence of interaction between PDE5 and signaling pathways involved in melanoma evolution and progression, including BRAF and NRAS. 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